Cannabidiol and Human Health

Cannabidiol: positive uses and effects

Firstly, uses of cannabidiol for human health are multiple and widely documented and, besides, its positive effects and therapeutic potential are relevant too.
In addition, such data are supported by scientific literature. For further information, please consult the section of the site dedicated to bibliography, to find the different items, consisting of scientific articles and monographs, relating to all the citations in the text.

Cannabidiol as anxiolytic and neuroleptic, in integration with psychotherapy and rehabilitation, (Bonaccorso, Ricciardi, Zangani, Chiappini, Schifano, 2019).

  • Sleep disturbance
  • Agoraphobia
  • Disorders from Panic Attacks
  • Obsessive Compulsive Disorder
  • Post-traumatic Stress Disorder
  • Eating Disorders
  • Substance Use Disorders and Addictive behavior disorders) (ludopathy, above all)
  • Borderline Personality Disorders
  • Schizophrenia and Bipolar Psychosis
  • Neurocognitive Disorders (Dementia)
  • Neurodevelopmental Disorders (Autism Spectrum Disorders and Attention Deficit and Hyperactivity Disorder)
  • Parkinson’s Disease and Parkinsonisms

Cannabidiol as an anti-inflammatory, painkiller, antispasmodic and immunomodulator (Nagarkatti, Pandey, Rieder, Hegde, Nagarkatti, 2009 and Peyravian, Deo, Daunert, Jimenez, 2020).

  • Headache
  • Irritable Bowel Syndrome (IBS)
  • Ulcerative colitis  and Chron’s disease
  • Inflammatory and degenerative diseases of the osteo-articular system such as arthritis and osteoarthritis
  • Premenstrual syndrome
  • Muscle pain
  • Neuralgia
  • Fibromyalgia
  • Multiple sclerosis
  • Covid-19

Cannabidiol as an antiaging agent (Baban, Khodadadi, Salles, Costigliola, 2001).

In the preventive treatment of the physiological decline, cognitive and physical, due to the process of senescence.

Also, as an activator of brain metabolic processes and as a substance able to reduce neuro-inflammatory and neuro-degenerative processes.

Cannabidiol in Cardiology (Stanley, Hind, O’Sullivan, 2013).

Properties and benefits: the cannabidiol antioxidant and anti-inflammatory action.

Cannabidiol has a positive effect on cardiovascular function, in fact it reduces the pressure-systolic and diastolic values in case of hypertension. Furthermore, It slows the heart rate when the frequency is too high for functional reasons, especially related to anxiety and stress. Moreover, cannabidiol demonstrates a vasodilating action that favors the lowering of the pressure and, above all, the perfusion of the various organs, with reference to the brain.

Thanks to its powerful anti-inflammatory and antioxidant action, cannabidiol acts positively on the atherosclerotic inflammation of the coronary and the entire vascular system, in order to promote the stabilization of the lesions in place and preventing the new formation. Especially, In the case of atherosclerosis, the systematic intake of cannabidiol, supplemented with the modification of harmful lifestyles -sedentary and feeding- qualitatively and quantitatively dysfunctional, contributes to the improvement of the state of the arterial walls. Cannabidiol also contributes to lower blood cholesterol levels. In fact this benefit is demonstrated by a 2013 study on the effect of cannabis on metabolic systems, comparing non-users with consumers.  –Above all, study analyzed some blood chemistry parameters of 4,652 participants and, in conclusion, its evidence showed that regular CBD users exhibited higher blood levels of high-density lipoprotein (HDL).

Cardiology 300x236

Cannabidiol as an immunomodulator (Nichols, Kaplan, 2020).

A recent scientific review has thoroughly analysed the effects of CBD on the regulation of immune system activities, both in vivo and in vitro.

Data from this review support the hypothesis that CBD has immunoregulatory effects, carried out by direct inhibition of pathogenic activity of different types of immune cells.

In fact, the regulatory action that cannabidiol exerts on the immune system has been shown to be therapeutic in the treatment of various diseases, characterized by an immune dysregulation, such as multiple sclerosis (Furgiuele, Cosentino, Ferrari, Marino, 2021)the ulcerative rectocolitis (De Filippis, Cirillo, Cipriano, et Al., 2011) and the Covid-19 (Nguyen. Yang, Nicolaescu et Al., 2021).

Moreover, a recent study (Nguyen, Yang, Nicolaescu et Al, 2022) showed that CBD and its metabolite 7-OH-CBD, block the replication of SARS-cov-2 in the pulmonary epithelial cells of laboratory mice. First of all, CBD acts after the virus enters the cells, inhibiting gene expression and reversing many effects of SARS-cov-2 on host gene transcription. CBD also inhibits SARS-cov-2 replication by over-regulating the endoplasmic reticulum (ER) stress response of IRE1α host ribonuclease and interferon signaling pathways. Further, in homogenous test groups of human patients of the National COVID Cohort Collaborative, a negative association was demonstrated between positive SARS-cov-2 tests and CBD administration (100 mg oral solution per patient, equivalent to ten drops of NegEnt). In conclusion, this study shows that CBD may be a potential preventative agent for SARS-cov-2 infection at an early stage and merits some more adequate scientific investigation in the near future.

Cannabidiol, Appetite and Metabolism (Bielawiec, Harasim-Symbor, Chabowski, 2020).

First, regular intake of cannabidiol can stabilize the food line, in order to improve mitochondrial functioning, and reduce insulin levels.

Above all, Cannabidiol, taken regularly, tends to stabilize and normalize dietary behavior, counteracting emotional eating and compulsive hunger. In fact, CBD promotes weight loss or the maintenance of healthy weight, thanks to the activation and improvement of mitochondrial functioning, thus stimulating the use by cells, nutrients, and their transformation into energy. Besides, the regular intake of CBD also decreases the high levels of insulin in the blood of people with metabolic syndrome due to a diet too rich in calories and carbohydrates and a sedentary life.

Cannabidiolo e Metabolismo
Cannabidiolo in Dermatologia

Cannabidiol in Dermatology (Sheriff, Lin, Dubin, Khorasani, 2020).

Effective remedy for skin diseases.

CBD has a strong anti-inflammatory, antipruritic and antibacterial activities and consequently, it suggests a topical use in dermatology. In other words, cannabidiol is considered an effective remedy for diseases such as dermatitis, acne and psoriasis. Moreover, medical devices based on CBD, proposed in the form of lotions and ointments, recently exist on the market. NegEnt can be applied directly to the skin, by means of the dropper; then you can stretch the solution on the area to be treated, with the fingertips, after washing and sanitizing the hands.

Cannabidiol in Dentistry (Larsen, Shahinas, 2020).

NegEnt: original and innovative product for the teeth and gums health. Cannabidiol is also an excellent remedy for the treatment of periodontitis, thanks to its anti-inflammatory, antibacterial and antioxidant actions and thanks to the absence of any side effects. In other words, Periodontitis is a condition that affects millions of people around the world, causing in fact the progressive loss of teeth, with all the complications associated with it. In conclusion, experimental scientific studies have shown that topical application of CBD on the gums of patients with periodontitis improves inflammation and the composition of bacteria in gum pockets, moreover, slowing the development of pathogenic species. In addition, it counteracts the progressive and pathological reduction of alveolar bone tissue (Karas, Wong, Paulin et Al., 2020; Napimoga, Benatti, Lima et Al.). Even more: the strong analgesic action of CBD reduces the suffering of patients and

also allows a progressive improvement in chewing function.

First, NegEnt introduces, in Dentistry, an original and innovative therapeutic concept, defined by Tullio Scrimali: edible mouthwash. In fact, a couple of drops of NegEnt, diluted in a few milliliters of water, can be used for buccal rinses, for the purpose of a local therapeutic action. Finally, being edible NegEnt, it is also possible to swallow the solution after rinsing, thus obtaining not only a topical action, but also

an anti-inflammatory and analgesic effect at a systemic level.

Cannabidolo per i denti
Cannabidiolo e Sessuologia

Cannabidiol and Sexology (Lynn, Gee, Zhang, Pfaus, 2020 and Bhambhvani, Kasman, Wilson-King, Eisenberg, 2020).

A valuable benefit for the sexuality of man and woman.

Cannabidiol in fact, used in sexology, reduces performance anxiety, improves desire

in both men and women. Further CBD counteracts erectile dysfunction and premature ejaculation. CBD based creams and lotions can also be useful in the integrated treatment of dyspareunia and vaginismus.

Cannabidiol in sports practice (Daniel Rojas-Valverde, 2021).

Anxiolytic and anti-stress effect without any sedative action.

In other words, the anti-inflammatory and antioxidant effect of cannabidiol, as well as anxiolytic and antistress, separated from any sedative action, is valuable in the practice of sports activities. Further, In the course of these activities, trauma or microtrauma can occur both in the joints and muscles; the production of free radicals and lactic acid could also be activated, with negative metabolic consequences.

Cannabidiolo nella pratica sportiva